I'm Russell.

thegeographia:

A map I created for my Cartography class this semester. I was doing a study on the interaction of tornadoes and highly populated areas. Yay maps!

(via time-for-maps)

home-dsign:

Chipicas Town Houses Valle de Bravo - Mexico

(via thatcoffeehouse)

on-ramp:

1959 Pontiac brochure illustration—Bonneville Vista 4-door sedan

This appears to be another AF and VK rendering although it lacks their luscious background style.

(via tears4gears)

bikesandgirlsandmacsandstuff:

(via Lockedcog.com – Bikes on the Streets. » Blog Archive » Robbie’s ’98 GT GTB.)

(via tears4gears)

pleoros:

Cody Cobb

(via rchtctrstdntblg)

(Source: pushthemovement)

archidose:

Rogers

(via rchtctrstdntblg)

(via notmybeautifulhome)

carolinastyle:

Kirk Miller

(via abitofcolor)

atavus:

Angel Sculpture in Rouen, France

Via [Annie Draco]

(Source: marieclairemaison.com, via notmybeautifulhome)

science-junkie:

Physicists, biologists unite to expose how cancer spreads

Cancer cells that can break out of a tumor and invade other organs are more aggressive and nimble than nonmalignant cells, according to a new multi-institutional nationwide study. These cells exert greater force on their environment and can more easily maneuver small spaces.

The researchers report in the journal Scientific Reports that a systematic comparison of metastatic breast-cancer cells to healthy breast cells revealed dramatic differences between the two cell lines in their mechanics, migration, oxygen response, protein production and ability to stick to surfaces. The researchers discovered new insights into how cells make the transition from nonmalignant to metastatic, a process that is not well understood.

The resulting catalogue of differences could someday help researchers detect cancerous cells earlier and someday prevent or treat metastatic cancer, which is responsible for 90 percent of all cancer deaths, according to the study. It was conducted by a network of 12 federally funded Physical Sciences-Oncology Centers (PS-OC) sponsored by the National Cancer Institute. PS-OC is a collaboration of researchers in the physical and biological sciences seeking a better understanding of the physical and chemical forces that shape the emergence and behavior of cancer…

Researchers with the Princeton PS-OC, for instance, determined that metastatic cells, in spite of moving more slowly than nonmalignant cells, move farther and in a straighter line, Robert Austin [professor of physics and leader of the Princeton PS-OC] said. The investigators studied the cells’ behavior in tiny cell-sized chambers and channels etched out of silicon and designed to mimic the natural environment of the body’s interior.

“The mobility of these metastatic cells is an essential feature of their ability to break through the tough membrane [the extracellular matrix] that the body uses to wall off the tumor from the rest of the body,” Austin said. “These cells are essentially jail-breakers.”…

Other notable findings from the paper include that metastatic cells recover more rapidly from the stress of a low-oxygen environment than nonmetastatic cells, which is consistent with previous studies. Although the low-oxygen environment did kill many of the metastatic cells, the survivors rebounded vigorously, underscoring the likely role of individual cells in the spread of cancer. The study also looked at total protein production and detected proteins in the metastatic cells that are consistent with the physical properties such as mobility that malignant cells need to invade the extracellular matrix…

For the nationwide project, nearly 100 investigators from 20 institutions and laboratories conducted their experiments using the same two cell lines, reagents and protocols to assure that results could be compared. The experimental methods ranged from physical measurements of how the cells push on surrounding cells to measurements of gene and protein expression…

“Roughly 20 techniques were used to study the cell lines, enabling identification of a number of unique relationships between observations,” Kuhn [program manager for the PS-OC at the National Cancer Institute] said.

For example, a technique known as atomic force microscopy indicated that metastatic cells are softer than nonmalignant cells whereas a different technique, traction force microscopy, suggested that metastatic cells exert more force on their surroundings, Kuhn said. Together these two findings may indicate that metastatic cells can exert force to stick to, migrate on and remodel the tough extracellular matrix that surrounds the tumor, while remaining flexible enough to squeeze through small spaces in that membrane.

Source: princeton.edu

Images: [x][x]

tears4gears:

Hampsten beaut.

(Source: gallifreyan-detective, via zoeelaine)